drug interaction case study examples

Introduction. The incidence of a clinical drug interactions 3-5% in pts taking 3 or fewer medication, but 20% in pts taking 10-20 drugs. 20% of hospital admissions result from an adverse drug event or a Drug-Drug Interaction. 60-80% of computerized DDI alerts are overridden.

Drug interactions occur on pharmacodynamic and pharmacokinetic levels. Examples of pharmacodynamic interactions are simultaneous administration of a NSAID and phenprocoumon (additive interaction), or of aspirin and ibuprofen (antagonistic interaction).

We report the case of a multiple drug interaction involving clozapine, antifungals and oral contraceptives, which resulted in an increased clozapine plasma level, pericarditis with pericardial effusion and eosinophilia in a young Caucasian woman.

Drug interactions. Severe DRESS with myocarditis secondary to naproxen/esomeprazole. Sarah O'Mahony, Ann-Marie Tobin, Teresa Mary Donnelly. BMJ Case Reports CP Apr 2024, 17 (4) e258187; DOI: 10.1136/bcr-2023-258187.

Case Study Answers and Discussion. Self-Assessment Answers. Presenter: Sarah Robertson, PharmD, Vertex Pharmaceuticals. This educational module examines the different kinds of drug interactions, the principal mechanisms that cause them, and how to understand complex drug interactions.

This chapter aims to discuss the drug interactions and provides real cases of drug interactions. Drug interactions can lead to serious adverse effects, which affect the treating outcomes, it can affect the clinical, economical, and humanistic outcome of treating patients.

The following case study illustrates the pharmacotherapeutic challenges of diabetes with other comorbidities, which can lead to potential drug-drug and drug-disease interactions.

We examined AE case reports for known DDIs and for potential interactions between drugs that can occur at the level of targets (DTIs) or metabolizing enzymes (DMIs). We also examined the prevalence of three classes of negative clinical outcomes (death, life threatening, hospitalization) in the context of five cancer indications.

Potential Drug-Drug Interactions (DDIs) in Pediatric Patients. Drug-drug interactions (DDI) are a serious concern in pharmacotherapy whereby the pharmacological effect of a victim drug is either exaggerated or suppressed by the concomitant administration of a perpetrator drug.

Sample Case. The first case we will consider is that of the potentially lethal arrhythmia, torsades de pointes, occurring in association with terfenadine (Seldane) use in a young woman. 1. This...